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1. Villarino AV, Kanno Y, Ferdinand JR, O'Shea JJ. J Immunol. 2015;194(1):21-27.

2. Schwartz DM, Kanno Y, Villarino A, Ward M, Gadina M, O'Shea JJ. Nat Rev Drug Discov. 2017;16(12):843-862.

3. Park SO, Wamsley HL, Bae K, et al. PLoS One. 2013;8(3):e59675.

4. Gotthardt D, Sexl V. Front Immunol. 2016;7:694.

5. Bottos A, Gotthardt D, Gill JW, et al. Nat Commun. 2016;7:12258.

6. Wang KS, Zorn E, Ritz J. Blood. 2001;97(12):3860-3866.

7. Hashizume M, Hayakawa N, Mihara M. Rheumatology (Oxford). 2008;47(11):1635-1640.

8. Van Roon JA, Glaudemans KA, Bijlsma JW, Lafeber FP. Ann Rheum Dis. 2003;62(2):113-119.

9. Van Roon JA, Hartgring SA, Wenting-van Wijk M, et al. Ann Rheum Dis. 2007;66(5):664-669.

10. McInnes IB, Leung BP, Sturrock RD, Field M, Liew FY. Nat Med. 1997;3(2):189-195.

11. Ferrari-Lacraz S, Zanelli E, Neuberg M, et al. J Immunol. 2004;173(9):5818-5826.

12. González-Alvaro I, Domínguez-Jiménez C, Ortiz AM, et al. Arthritis Res Ther. 2006;8(4):R88.

13. Li J, Shen W, Kong K, Liu Z. Scand J Immunol. 2006;64(5):515-522.

14. Xing R, Yang L, Jin Y, et al. Scand J Immunol. 2016;83(1):64-71.

15. Kwok SK, Cho ML, Park MK, et al. Arthritis Rheum. 2012;64(3):740-751.

16. McInnes IB, Schett G. Nat Rev Immunol. 2007;7(6):429-442.

17. Churchman SM, Ponchel F. Rheumatology (Oxford). 2008;47(6):753-759.

18. Dinesh P, Rasool M. J Cell Physiol. 2018;233(5):3918-3928.

19. Kurowska M, Rudnicka W, Kontny E, et al. J Immunol. 2002;169(4):1760-1767.

20. Srirangan S, Choy EH. Ther Adv Musculoskelet Dis. 2010;2(5):247-256.

21. Barnes TC, et al. In: Tak PP, ed. Progress in Inflammation Research. Basel, Switzerland: Birkhäuser Basel; 2009:181-191.

22. Jang J, Lim DS, Choi YE, et al. Arthritis Res Ther. 2006;8(6):R170.

23. Reynolds G, Gibbon JR, Pratt AG, et al. Ann Rheum Dis. 2016;75(5):899-907.

24. Schurgers E, Billiau A, Matthys P. J Interferon Cytokine Res. 2011;31(12):917-926.

25. McHugh NJ, Tansley SL. Nat Rev Rheumatol. 2018;14(5):63.

26. Karonitsch T, Beckmann D, Dalwigk K, et al. Rheumatology (Oxford). 2018;57(3):572-577.

27. Winthrop KL. Nat Rev Rheumatol. 2017;13(4):234-243.

28. O’Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A. Annu Rev Med. 2015;66:311-328.

Proper JAK-STAT pathway signalling is essential for normal immunological function1

Essential immunological functions depend on the dynamic equilibrium of the JAK-STAT pathway.1

Physiological disruptions and inflammatory diseases, such as RA, have been associated, respectively, with deficient and excessive JAK-STAT pathway signalling.2-15

The importance of normal JAK-STAT pathway signalling
Excessive cytokine signalling

Excessive cytokine signalling via certain JAK pairings is associated with typical signs of RA pathology, such as bone destruction, inflammation, and autoimmunity.16-26

Deficient cytokine signalling

A number of cytokines signal through JAK-STAT pathways by binding to their associated receptors.1

Understanding the JAK-STAT pathway and its role in essential immunological and physiological functions may help to advance the research of inflammatory diseases.1,27,28
For news on the partnership’s continuing innovation in RA, subscribe here.

NEXT: UNMET NEEDS

References: 1. Villarino AV, et al. J Immunol. 2015;194:21-27. 2. Schwartz DM, et al. Nat Rev Drug Discov. 2017;16:843-862. 3. Park SO, et al. PLoS One. 2013;8:e59675. 4. Gotthardt D, et al. Front Immunol. 2016;7:694. 5. Bottos A, et al. Nat Commun. 2016;7:12258. 6. Wang KS, et al. Blood. 2001;97:3860-3866. 7. Hashizume M, et al. Rheumatology (Oxford). 2008;47:1635-1640. 8. van Roon JA, et al. Ann Rheum Dis. 2003;62:113-119. 9. van Roon JA, et al. Ann Rheum Dis. 2007;66:664-669. 10. McInnes IB, et al. Nat Med. 1997;3:189-195. 11. Ferrari-Lacraz S, et al. J Immunol. 2004;173:5818-5826. 12. González-Alvaro I, et al. Arthritis Res Ther. 2006;8:R88. 13. Li J, et al. Scand J Immunol. 2006;64:515-522. 14. Xing R, et al. Scand J Immunol. 2016;83:64-71. 15. Kwok SK, et al. Arthritis Rheum. 2012;64:740-751. 16. McInnes IB, et al. Nat Rev Immunol. 2007;7:429-442. 17. Churchman SM, et al. Rheumatology (Oxford). 2008;47:753-759. 18. Dinesh P, et al. J Cell Physiol. 2018;233:3918-3928. 19. Kurowska M, et al. J Immunol. 2002;169:1760-1767. 20. Srirangan S, et al. Ther Adv Musculoskelet Dis. 2010;2:247-256. 21. Barnes TC, et al. In: Tak PP, ed. Progress in Inflammation Research. Basel, Switzerland: Birkhäuser Basel; 2009:181-191. 22. Jang J, et al. Arthritis Res Ther. 2006;8:R170. 23. Reynolds G, et al. Ann Rheum Dis. 2016;75:899-907. 24. Schurgers E, et al. J Interferon Cytokine Res. 2011;31:917-926. 25. McHugh NJ, et al. Nat Rev Rheumatol. 2018;14:63. 26. Karonitsch T, et al. Rheumatology (Oxford). 2018;57:572-577. 27. Winthrop KL. Nat Rev Rheumatol. 2017;13:234-243. 28. O’Shea JJ, et al. Annu Rev Med. 2015;66:311-328.