Proper JAK-STAT pathway signalling is essential for normal immunological function1
Essential immunological functions depend on the dynamic equilibrium of the JAK-STAT pathway.1
Physiological disruptions and inflammatory diseases, such as RA, have been associated, respectively, with deficient and excessive JAK-STAT pathway signalling.2-15



Excessive cytokine signalling via certain JAK pairings is associated with typical signs of RA pathology, such as bone destruction, inflammation, and autoimmunity.16-26


A number of cytokines signal through JAK-STAT pathways by binding to their associated receptors.1
