Experts discuss RA pathogenesis
Discusses the immune system as a complex network which relies on cytokines to respond to pathogens. Highlights the role of JAK-dependent cytokines in various processes associated with RA pathogenesis.
Details JAK-mediated cytokine signalling and highlights key cytokines associated with RA (IL-6, IL-21, GM-CSF) and their role in disease pathogenesis.
Introduces the Janus kinase family of proteins (JAK1, JAK2, JAK3 and TYK2) and details the structural similarities between JAK family proteins. Differences in immunological function between JAK family proteins are discussed.